Cafestol Compound In Coffee Found To Potentially Aid Weight Loss Without Dieting – CoffeeTalk

A Danish trial suggests that certain types of coffee, such as espresso, French press, and Turkish coffee, may help people lose weight without dieting. The study team, led by lead investigator Frederik D. Mellbye from Steno Diabetes Center Aarhus, wanted to know if purified cafestol could change markers tied to obesity and diabetes. Participants who received cafestol lost an average of 1.94 lbs of body weight over twelve weeks. In the 12-week, placebo-controlled study, 40 adults with large waistlines swallowed either 6 mg of cafestol or an inert capsule twice daily.

Unfiltered coffee already intrigues metabolic researchers because habitual drinkers show lower rates of type 2 diabetes. Isolating cafestol allowed the Danish scientists to test whether weight and fat changes might happen without the full brew. The results revealed that visceral fat fell by five percent in the cafestol group, corresponding to 440 mL of lost internal fat that wraps organs and drives disease risk. Weight dropped two percent, while the placebo group gained almost a kilogram during the same period. Liver health improved as well, with gamma-glutamyl transferase (GGT) falling 15 percent among cafestol takers, a notable shift because high GGT predicts diabetes onset. Fasting glucose, blood pressure, and subcutaneous fat barely budged, suggesting the molecule targets deep abdominal fat first.

Cafestol differs from other coffee compounds by dissolving in coffee oils that paper filters remove, which explains why a French press tastes richer and delivers more of the molecule. Animal work previously linked cafestol to better insulin secretion, but the new human data found no change in insulin sensitivity. The authors note that a higher dose or longer trial might reveal effects that 12 weeks at 12 mg per day could not capture.

Losing visceral fat matters because this depot floods the bloodstream with free fatty acids, a driver of insulin resistance and inflammation. By trimming that hidden fat without strict dieting, cafestol hints at a new nutrition-based tool against metabolic syndrome. The findings echo earlier work with green coffee extract, where chlorogenic acids modestly lowered body-mass index (BMI) in overweight adults.

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